Regions which are Responsible for Swapping are also Responsible for Folding and Misfolding

Regions which are Responsible for Swapping are also Responsible for Folding and Misfolding

Domain swapping is a term used to describe a process when two or more protein chains exchange identical structural elements. Some cases of amyloid formation can be explained through a domain swapping mechanism therefore this deserves theoretical consideration and studying. It has been demonstrated that diverse proteins in sequence and structure are able to oligomerize via domain swapping. This ...

Are Environmental Contaminants Responsible for ‘Globesity’?

According to the World Health Organization (WHO), worldwide obesity has nearly doubled since 1980. In the previous year 42 million children under the age of 5 were overweight or obese. The concern of governments, the scientific community, and health services is noticed in the causes behind the prevalence of obesity and its prevention. Taking into consideration the reasons underlying obesity, to...

Are mergers responsible for universal halo properties?

N -body simulations of Cold Dark Matter (CDM) have shown that, in this hierarchical structure formation model, dark matter halo properties, such as the density profile, the phase-space density profile, the distribution of axial ratio, the distribution of spin parameter, and the distribution of internal specific angular momentum follow ‘universal’ laws or distributions. Here we study the propert...

Are You Responsible for Your Hormones?

A DMA and oxidative stress are responsible for endothelial dysfunction

Objectives: Hyperhomocyst(e)inemia is a risk factor for atherosclerotic vascular disease, and it is associated with endothelial dysfunction. Mechanisms responsible for endothelial dysfunction in hyperhomocyst(e)inemia may involve impaired bioavailability of NO, possibly secondary to accumulation of the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) and increased oxidative s...